Oligonucleotide CRO&CDMO

Shanghai Aurisco Biotech Co., Ltd is focus on providing CRO/CDMO services. We provide APIs service from discovery, clinical trialsto commercial stage.

With 20+ years’ experience of API manufacturing, our oligo platform has a dedicated team of 30+ scientists in oligonucleotide field, accelerating clients’ drugs to the global market.

The process chemistry, analytical, and regulations teams collaborate to provide clients with a fast, efficient, and flexible integrated solution for oligonucleotide development.

Advanced equipments

Aurisco oligonucleotide platform is equipped with Cytiva ÄKTA oligonucleotide solid-phase synthesizer and purification equipments,with capacity from gram to KG scale.

In addition, analytical equipments including UPLC-QTof, UPLC-MS, UPLC provide support for oligonucleotide structure characterization, analytical method development and validation,GMP manufacturing and stability study.

  • Lab scale(grams)

    ÄKTA OligoPilot 10, 100ÄKTA flow 6
  • Pilot scale (hundreds grams)

    OligoPilot™ 2000Novasep Hipersep™Sartoflow advancedGenesis 35L
  • Key analytical equipment

    Headspace GCUHPLC, UPLCUPLC-UV-MS, UHPLC-TOF-MS

Manufacturing capbility

Custom DNA/RNA - API Manufacturing Services

Aurisco provides oligonucleotide synthesis services as follow

  • 01ASO
  • 02PMO
  • 03siRNA
  • 04miRNA
  • 05Other modified oligonucleotides
  • 06Decoy ODNs
  • 07Aptamer
  • 08Locked nucleic acid (LNA)
  • 09DNA Probe, RNA Probe
  • 10Others:modified nucleosides, nucleotides; Delivery System chemicals

Oligonucleotide Service includes

  • Process Developing and Optimization
  • mg to KG scale
  • Analytical characterization, test method development and validation, IPC & release testing
  • Stability studies compliant to ICH
  • RA support for worldwide