Oligonucleotide CRO&CDMO
Shanghai Aurisco Biotech Co., Ltd is focus on providing CRO/CDMO services. We provide APIs service from discovery, clinical trials to commercial stage.
With 20+ years’ experience of API manufacturing, our oligo platform has a dedicated team of 30+ scientists in oligonucleotide field,and equips with advanced and equipment,accelerating clients’ drugs to the global market.
The process chemistry, analytical, and regulations teams collaborate to provide clients with a fast, efficient, and flexible integrated solution for oligonucleotide development.
Advanced equipments
Aurisco oligonucleotide platform is equipped with Cytiva ÄKTA oligonucleotide solid-phase synthesizer and purification equipment,with capacity from gram to KG scale.
In addition, analytical equipments including UPLC-QTof, UPLC-MS, UPLC provide support for oligonucleotide structure characterization, analytical method development and validation,GMP manufacturing and stability study.
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Lab scale(grams)
ÄKTA OligoPilot 10ÄKTA OligoPilot 100ÄKTA Pure 25ÄKTA Pure 150ÄKTA flux 6Lyophilyzer Xinzhi -
Pilot scale (hundreds grams)
OligoPilot™ 2000Novasep Hipersep™Sartoflow advancedGenesis 35L -
Key analytical equipment
UHPLC,UPLC(IP-RP, IEX, SEC)LC-MS(ESI, Quadrupole)UPLC-HRMS(ESI, Q-tof)Headspace GCUV-VIS(Temperature controlled)
Manufacturing capability
Custom DNA/RNA - API Manufacturing Services
Aurisco provides oligonucleotide synthesis services as follow
- 01ASO
- 02siRNA
- 03Aptamer
- 04CpG ODN
- 05Other new oligos
- 06Oligos Conjugations
- 07Others：modified nucleoside，impurity, modified GalNAc or Lipid
Oligonucleotide Service includes
- Process Developing and Optimization
- mg to KG scale
- Analytical characterization, test method development and validation, IPC & release testing
- Stability studies compliant to ICH
- RA support for worldwide
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